Metabolism of glycerolipids: V. Metabolism of phosphatidic acid
نویسندگان
چکیده
منابع مشابه
Metabolism of Glycerolipids
Phosphatidylethanolamine or phosphatidylcholine may be synthesized in mammalian tissues from diglycerides and cytidine diphosphate ethanolamine or cytidine diphosphate choline, respectively (1). Hydrolysis of the naturally occurring phosphatides has indicated that often the fatty acids at the @ position are unsaturated whereas those at (Y’ are more often saturated (2-4). Although it is possible...
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Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...
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We determined that lisofylline, a potent inhibitor of oleate- and linoleate-containing phosphatidic acid formation (half-maximal inhibitory concentration = 40 nM), prevented oxidant-mediated capillary leak in isolated rat lungs given interleukin-8 (IL-8) intratracheally and perfused with human neutrophils. Lung leak was prevented by lung, but not neutrophil, lisofylline pretreatment. Furthermor...
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In the course of W-tracer studies on the biological synthesis of lecithin in lung tissue slices, the ratio of fatty acid activity to glycerol activity in lecithin was higher than in the triglyceride fraction. It was suggested that the observed isotope distributions could be due to turnover of the fatty acid portion of lecithin without a corresponding synthesis and breakdown of the remainder of ...
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Due to its genetic tractability and increasing wealth of accessible data, the yeast Saccharomyces cerevisiae is a model system of choice for the study of the genetics, biochemistry, and cell biology of eukaryotic lipid metabolism. Glycerolipids (e.g., phospholipids and triacylglycerol) and their precursors are synthesized and metabolized by enzymes associated with the cytosol and membranous org...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1964
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)40264-0